Logitech Harmony one buy

Logitech Harmony One
Advanced Universal Remote

Got it, and love it. I have used universal remotes before, but they have NEVER EVER learned all of the commands, i.e. DVR for the cable box. This remote absolutely does this. It has an extremely easy setup - just plug into the computer and follow the prompts. You can also rearrange the buttons to the way that you like the layout. The only thing it doesn't work for is the Wii, since it is IR technology. However, it changes the input of the TV, which is one less step I would have to do. This remote is awesome, it does everything I want it to and it fits comfortably in my hand.